George Vernon Meredith Frampton [commonly known as Mededith Frampton] was born in St. John's Wood, London, England on 17 March 1894. He was the son of the sculptor Sir George James Frampton (1860-1928), and the painter Christabel Annie Cockerell (1863-1951) and studied at St. John's Wood School of Art and the Royal Academy Schools in London from 1912 to 1915.

During World War One he served in the Artists' Rifles. He also worked on the Western Front with a field survey company and in interpretation of aerial photographs. Following the war, he embarked on a career as a painter, principally of portraits. Among his sitters were the Duke of York (later King George VI), the conductor Sir Henry Wood, the architect Sir Edwin Lutyens, the writer Sir Henry Newbolt, and Sir Ernest Gowers, Senior Regional Commissioner for Civil Defence, London Region (1940–45). The latter portrait was commissioned by the War Artists' Advisory Committee.

Frampton exhibited at the Royal Academy in London virtually every year from 1920 to 1940. He also exhibited at the International Society of Society of Sculptors, Painters and Gravers in London; Manchester City Art Gallery; and at the Walker Art Gallery in Liverpool. He was elected an Associate of the Royal Academy (ARA) in 1934 and a Royal Academician (RA) in 1942. He was also elected a member of the Art Workers Guild in 1915.

Frampton's painting "Portrait of a Young Woman" was purchased by the Chantry Bequest in 1935.

After 1948 he rarely painted due to failing eyesight. A retrospective exhibition of his work was held at the Tate Gallery in London in 1982, two years before his death. He died at his home, Mount Pleasant, Castle Hill Lane, Mere, Wiltshire, on 16 September 1984.